Lymphoma is a type of cancer that affects the lymphatic system, which is a network of tissues and organs that helps to protect the body from infections and diseases. Lymphoma occurs when cells in the lymphatic system begin to grow and divide abnormally, forming tumors that can interfere with the normal function of the immune system.
According to the American Cancer Society, there are an estimated 92,000 new cases of lymphoma diagnosed each year in the United States, and about 20,000 people die from the disease annually.
Non-Hodgkin lymphoma is more common than Hodgkin lymphoma, accounting for about 90% of all cases of lymphoma. The incidence of non-Hodgkin lymphoma increases with age, and it is more common in men than in women. The incidence of Hodgkin lymphoma is lower than non-Hodgkin lymphoma, accounting for about 10% of all cases of lymphoma. Hodgkin lymphoma is more common in young adults and older adults, and it affects men and women equally.
The incidence and prevalence of lymphoma can also vary by geographic region and other factors. For example, certain subtypes of lymphoma may be more common in certain parts of the world or in people with certain genetic or environmental risk factors.
Types of Lymphoma:
There are two main types of lymphoma: Hodgkin lymphoma and non-Hodgkin lymphoma. Here is a more detailed description of the subtypes of lymphoma:
Hodgkin Lymphoma: Hodgkin lymphoma is a relatively rare type of lymphoma, accounting for about 10% of all cases of lymphoma. Hodgkin lymphoma is characterized by the presence of abnormal cells called Reed-Sternberg cells, which are a type of white blood cell that is not normally found in the lymphatic system. There are several subtypes of Hodgkin lymphoma, including:
1. Classic Hodgkin lymphoma: This is the most common subtype of Hodgkin lymphoma, accounting for about 95% of all cases of Hodgkin lymphoma. Classic Hodgkin lymphoma is further divided into four subtypes based on the appearance of the Reed-Sternberg cells and other factors.
2. Nodular lymphocyte-predominant Hodgkin lymphoma: This is a rare subtype of Hodgkin lymphoma that accounts for about 5% of all cases of Hodgkin lymphoma. Nodular lymphocyte-predominant Hodgkin lymphoma is characterized by the presence of popcorn-shaped cells called lymphocytic and histiocytic cells.
Non-Hodgkin Lymphoma: Non-Hodgkin lymphoma includes a wide range of subtypes that can vary in their appearance, behavior, and response to treatment. Non-Hodgkin lymphoma is further divided into two main categories:
1. B-cell lymphoma and T-cell lymphoma.B-cell lymphoma: B-cell lymphoma is the most common subtype of non-Hodgkin lymphoma, accounting for about 85% of all cases. B-cell lymphoma can be further divided into many subtypes, including diffuse large B-cell lymphoma, follicular lymphoma, mantle cell lymphoma, and marginal zone lymphoma.
2. T-cell lymphoma: T-cell lymphoma is a less common subtype of non-Hodgkin lymphoma, accounting for about 15% of all cases. T-cell lymphoma can be further divided into many subtypes, including peripheral T-cell lymphoma, anaplastic large cell lymphoma, and angioimmunoblastic T-cell lymphoma.
Other Subtypes:
In addition to Hodgkin lymphoma and non-Hodgkin lymphoma, there are other subtypes of lymphoma that are less common. These subtypes include:
1. Primary central nervous system lymphoma: This is a rare type of lymphoma that occurs in the brain or spinal cord.
2. Cutaneous lymphoma: Cutaneous lymphoma is a type of lymphoma that affects the skin.
3. AIDS-related lymphoma: AIDS-related lymphoma is a type of lymphoma that occurs in people with HIV/AIDS.